![]() Īny additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.Īn original code used for determining ploidy (gene copy number) and allele genotype of KIR is available at with reference data curated from IPD-KIR allele database, both of which are publicly available ( ).Other web resources used in this study are listed in the key resources table. Accession numbers are listed in the key resources table. The genotype data of BBJ used in this study are available from the Japanese Genotype-phenotype Archive (JGA) through application at. The International Histocompatibility Working Group (IHWG) cell lines were obtained from ECACC HLA typed collection ( ). The genomic DNA we used for KIR sequencing were obtained from a cell line established by the Japan Biological Informatics Consortium (JBIC), and can be purchased at. The ethics committees of GenoDive Pharma Inc. They are searchable and most databases found at your library provide credible, published content. (2013) Detection of Ancestry Informative HLA Alleles Confirms the Admixed Origins of Japanese Population. An online database is an electronic collection of information. ![]() Accession numbers are listed in the key resources table. Citation: Nakaoka H, Mitsunaga S, Hosomichi K, Shyh-Yuh L, Sawamoto T, Fujiwara T, et al. low power in our case) using stratified Mantel tests in GENODIVE to permute the locations of. Individual-level KIR alleles and KIR imputation reference panel used in this study are deposited at the National Bioscience Database Center (NBDC) Human Database ( ) and are publicly available as of the date of publication. View metadata, citation and similar papers at core.ac.uk. The program was made with both diploids and polyploids in mind: all analyses can be. Our pipeline presents a broadly applicable framework to evaluate innate immunity in large-scale datasets. GenoDive is the premier Mac-application for population genetic analyses. ![]() We observe a dearth of genome-wide significant associations, even in immune traits implicated previously to be associated with KIR (the smallest p = 1.5 × 10 −4). We construct a KIR imputation reference panel (n reference = 689, imputation accuracy = 99.7%), apply it to biobank genotype (n total = 169,907), and perform phenome-wide association studies of 85 traits. We define 118 alleles in 13 genes and demonstrate a linkage disequilibrium structure within and across KIR centromeric and telomeric regions. Yes Is the work clearly and accurately presented and does it cite the current. We devise a bioinformatics pipeline incorporating copy number estimation and insertion or deletion (indel) calling for high-resolution KIR genotyping. Reference Source Meirmans PG van Tienderen PH : genotype and genodive: Two. Here we conduct deep sequencing of 16 KIR genes in 1,173 individuals. Despite its role in immunity, the complex genomic structure has limited a deep understanding of the KIR genomic landscape. The killer cell immunoglobulin-like receptor (KIR) recognizes human leukocyte antigen (HLA) class I molecules and modulates the function of natural killer cells.
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