![]() Spindle Cell Cancer could therefore be seen as an end result of a systemic and prolonged assault on blood and the immune system in general, which may never have appeared without late 20th century feeding practices. This change in diet and feeding practice after almost 5000 years living with humans can be seen as sudden and detrimental to canine health. In addition the domesticated dog is almost never allowed to bury and retrieve a bone and many never have raw meat in their diet at all. Also, their eating patterns have been subverted by over feeding so as to deny the long periods of fasting which they experienced in nature and which allowed their metabolism to clear toxins. The causes are open to debate but it is believed that a generalised breakdown of the metabolic and immune systems and bodily processes of the dog underlie the development of these cancers.ĭogs systems are called upon to digest far too much processed food since the advent of commercial dog feed in the 1950's. Vet Pathol 48 (1), 73-84 PubMed.Along with lymphoma and osteosarcoma, spindle cell cancer is becoming much more common in companion dogs nowadays. Dennis M M, McSporran K D, Bacon N J et al (2011) Prognostic factors for cutaneous and subcutaneous soft tissue sarcomas in dogs.Demetriou J L, Brearley M J, Constantino-Casas F et al (2012) Intentional marginal excision of canine limb sarcomas followed by radiotherapy.Bray J P (2016) Soft tissue sarcoma in the dog - part 1: a current review.Bray J P (2017) Soft tissue sarcoma in the dog - part 2: surgical margins, controversies and a comparative review.Linden D, Liptak J M, Vinayak A et al (2019) Outcomes and prognostic variables associated with primary abdominal visceral soft tissue sarcomas in dogs: A Veterinary Society of Surgical Oncology retrospective study.Giancarlo A, Roberta R, Chambers J K, Miller A D et al (2021) Review of Histological Grading Systems in Veterinary Medicine.Recent references from PubMed and VetMedResource.Hemangiosarcoma - vascular endothelium Hemangiosarcoma.įurther Reading Publications Refereed papers.Histiocytic sarcoma - dendritic cell origin Malignant histocytosis.Synovial (cell) sarcoma Synovial cell sarcoma.The following may also be described as soft tissue sarcoma, but are ‘excluded’ from the following general description / management because their biological behavior is more aggressive:.Some poorly differentiated tumors which lack cellular / stromal features to indicate tissue of origin may be referred to as ‘poorly differentiated’ or ‘anaplastic’ sarcoma.(Hemangiopericytoma Hemangiopericytoma - most now reclassified as PNST).Leiomyosarcoma - smooth muscle Leiomyoma /Leiomyosarcoma.Peripheral nerve sheath tumor (PNST) Nerve sheath: neoplasia.Fibrosarcoma - fibrous connective tissue (when evidence of collagen formation is lacking, often referred to as ‘spindle cell sarcoma’).According to presumed tissue of origin based on histological appearance of neoplastic cells and stroma:.Rarely arise at sites of burns or implants.Occasionally associated with chronic inflammation. ![]() Prognosis: based on histological grade, mitotic index and evaluation of margins.Treatment: surgical resection +/- radiotherapy.Peripheral nerve sheath tumor Nerve sheath: neoplasia.Signs: firm, fibrous mass affecting skin/subcutis, may be adherent to underlying tissue, slow growing.STS account for 15-20% of all canine tumors: although incidence can vary according to breed - see below.The malignant counterparts are generally referred to as ‘soft tissue sarcomas’ (STS) as they mostly present, behave, and are treated, in a similar manner. These tumors by definition do not metastasize and they generally only cause clinical problems by their size or location. The benign mesenchymal tumors, eg fibroma, are quite rare, locally expansile tumors that are cured by local surgical excision. Soft tissue sarcoma are tumors arising from mesenchymal connective tissues. They are usually grouped together as they generally behave in a similar manner.
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